Cytokines, infections, stress, and dysphoric moods in breastfeeders and formula feeders.

نویسندگان

  • Maureen W Groer
  • Mitzi W Davis
چکیده

OBJECTIVE To analyze relationships between stress, moods, and immunity in breastfeeding compared to formula-feeding mothers. DESIGN A cross-sectional study of 181 healthy mothers, exclusively breastfeeding or formula feeding, studied at 4 to 6 weeks after childbirth. SETTING Mothers were recruited in the postpartum unit of the hospital and then visited in their homes once at 4 to 6 weeks after childbirth for data collection. MAIN OUTCOME MEASURES Stress, mood, infection symptoms, and serum levels of interferon-gamma and interleukin-10 were measured. RESULTS Formula-feeding mothers had evidence of decreased interferon-gamma and a decreased serum Th1/Th2 ratio (interferon-gamma/interleukin-10) when perceived stress, dysphoric moods, and negative life events were high, an effect consistent with depression of cellular immunity. However, women who were breastfeeding did not show these relationships. CONCLUSIONS The data suggest that breastfeeding confers some psychoneuroimmunological benefit to mothers, perhaps through prolactin or hypothalamic-hypophyseal-adrenocortical axis stress refractoriness.

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عنوان ژورنال:
  • Journal of obstetric, gynecologic, and neonatal nursing : JOGNN

دوره 35 5  شماره 

صفحات  -

تاریخ انتشار 2006